MRCx™ Growth Factors
The MRCx patented process begins by harvesting human fibroblasts from a neonatal cell bank and culturing them in pure, bovine-free media.
The cells are then anchored to all-natural dextran microbeads and suspended in a culture chamber while the oxygen tension is lowered from atmospheric levels of 21% down to less than 5%.
During the conditioning process, the beads are gently and constantly stirred to allow unrestricted movement. The combination of gentle suspension and low oxygen levels mimics an embryonic environment.

This allows the cells to revert back to an embryonic-like state and exhibit stem cell properties. They release multipotent growth factors which are then collected to make MRCx.

The multipotent growth factors are then collected to make MRCx.

Clinical Studies
  • Human Cell-Conditioned Media Produced Under Embryonic-Like Conditions Result in Improved Healing Time After Laser Resurfacing

    M.P. Zimber, J.N. Mansbridge, M. Taylor, T. Stockton, M. Hubka, M. Baumgartner, L. Rheins, K. Hubka, E.N. Brandt, R. Kellar, G.K. Naughton
  • Hypoxic conditioned culture medium from fibroblasts grown under embryonic-like conditions supports healing following post-laser resurfacing

    Robert S Kellar, PhD,1 Mark Hubka, DC, FACO, MBA,1 Lawrence A Rheins, PhD,1 Garth Fisher, MD, FACS,2 & Gail K Naughton, PhD1
    1. Histogen, Inc., La Jolla, California, USA
    2. Biomedical Skin Treatment Institute and CellCeuticals Skin Care, Inc., Beverly Hills, California, USA
  • Anti-Aging Proof of Concept Study: Results and Summary

    S. Bruce1, J. Karnik2, L. Dryer3, D. Burkholder4
    1. The Center for Skin Research, Suzanne Bruce and Associates, Houston, TX
    2. Suneva Medical, Inc., Santa Barbara, CA
    3. Obagi Medical Products, Inc., Long Beach, CA
    4. PD Pharmaceutical Consulting, Guilford, CT