What is Regenica®?

Regenica® is a skin care system made with the power and promise of regenerative science. Its MRCx™ next generation growth factor technology is formulated to improve skin’s natural repair and renewal to reveal your most beautiful skin.

What does Regenica® do?

Regenica® with MRCx™ next generation growth factor technology enhances skin’s natural ability to repair and renew itself. Clinical studies prove that when used consistently, Regenica® improves the appearance of fine lines and wrinkles, reduces the appearance of pores, and evens out skin tone appearance to reveal a more radiant complexion

What makes Regenica® unique?

Only Regenica® is made with MRCx™ next generation growth factor technology. This proprietary, patented process creates younger, fresher growth factors unlike any other growth factor product. It’s designed for those who want to advance to the next level of skin care in order to help prevent and reverse the signs of aging.

How was Regenica® developed?

Regenica® was developed by Dr. Gail Naughton, one of the original developers of TNS® — an early growth factor technology. As she continued and advanced her research, she was struck by the fact that an unborn child could have surgery, yet have no scars at birth. She studied what was unique about the prenatal environment and found a way to mimic it, so that she could produce the same type of multipotent growth factors that are associated with scarless healing. This led to her development of MRCx™, the latest breakthrough in growth factor skin care.

Who is Dr. Gail Naughton?

Dr. Gail Naughton, Ph.D., is a leading regenerative scientist and researcher who has held numerous academic and Board appointments. As the founder of Advanced Tissue Sciences, she helped develop and pioneer the use of collagen as a tissue alternative. It was there that Dr. Naughton and her teammates recognized that the nutrients used in the conditioning process to make collagen might also be used in skin care. In the 1990s, this discovery gave rise to Nouricel MD™, which later became known as Tissue Nutrient Solution (TNS®). Dr. Naughton continued her research in regenerative science, particularly in embryonic scarless wound healing. Her research led to the development of MRCx™ next generation growth factor technology, the latest breakthrough in growth factor skin care.

Who should use Regenica®?

The Regenica® system with MRCx™ next generation growth factor technology is designed for patients who want to advance to the next level of skin care to help prevent and reverse the signs of aging. Used alone or in combination with other products, it’s part of a balanced skin care regimen to restore optimal skin health.

How should Regenica® be stored?

Regenica® has been specially packaged to protect the patented growth factor complex from exposure to the air. It has been formulated to be stable. For optimal results, keep product away from sun and in an environment below 77 °F.

What is MRCx™?

MRCx™ is next generation growth factor technology made by a proprietary, patented process. It is a blend of physiologically balanced growth factors that are naturally secreted by human fibroblasts. These fibroblasts have been cultured and nourished to enable them to revert back to an embryonic-like state and exhibit stem cell properties. The result is younger, fresher growth factors.

How is MRCx™ made?

The MRCx™ patented process begins by harvesting human fibroblasts from a neonatal cell bank and culturing them in pure, bovine-free media. The cells are then anchored to all-natural dextran microbeads and suspended in a culture chamber while the oxygen tension is lowered from atmospheric levels of 21% down to less than 5%. During the conditioning process, the beads are gently and constantly stirred to allow unrestricted movement. The combination of gentle suspension and low oxygen levels mimics an embryonic environment. This allows the cells to revert back to an embryonic-like stage and exhibit stem cell properties. They release multipotent growth factors which are then collected to make MRCx™.

How does MRCx™ work?

The growth factors in MRCx™ enhance the skin’s natural ability to repair and renew itself by supplementing the growth factors that are lost overtime.

What does multipotent mean?

Next generation technology uses a unique nourishing and culturing process in which young fibroblast cells revert back to a stem cell-like state, allowing them to secrete multipotent growth factors. Think of them like “multitasking” growth factors that work with young and old skin to optimize skin health. In short, these younger, fresher cells create younger, fresher, multipotent growth factors that are clinically proven to improve the appearance of skin.

Where do the cells used in MRCx™ come from?

Human fibroblasts are harvested from a proprietary cell bank.

Is MRCx™ affected by oxidation?

Regenica® with MRCx™ next generation growth factor technology has been specially packaged in an airless vacuum pump to protect the patented growth factor complex from exposure to the air (oxidation) and it has been formulated to be stable. For optimal results, keep product away from sun and in an environment below 77°F.

What is an embryonic environment and why is it beneficial?

Surgery done in utero results in scarless wound healing. The embryonic environment of hypoxia, suspension, and unrestricted movement changes the way the skin acts and heals itself. By recreating these conditions, MRCx™ captures the unique blend of multipotent growth factors that are present when skin is at its most regenerative state.

How is MRCx™ listed on the package?

MRCx™ in Regenica® is listed as human fibroblast conditioned media.

How does Regenica® differ from other growth factor products?

Regenica® was developed using the latest technological and scientific methods. The proprietary, patented conditioning process uses only pure nutrients and no bovine serum. While conventional culturing techniques use atmospheric oxygen levels of 21%, Regenica® creates an embryonic-like environment by reducing oxygen levels to less than 5% and maintaining the cells in suspension with constant, gentle motion. This process allows the cells to revert back to an earlier state and exhibit stem cell properties, causing the cells to release multipotent growth factors, unlike any other growth factor product.

What is a growth factor?

Growth factors are messenger proteins that occur naturally in our bodies and are key to sustaining optimal skin health.

Why do we need growth factors?

The skin is a complex organ that uses growth factors to maintain a homeostatic balance. By supplementing what the body naturally needs and loses with age, growth factors are able to target the key signs of aging.

Where do growth factors come from?

Growth factors are natural proteins that are created by cells, and released to send signals to other cells.

Are growth factors safe?

The growth factors in MRCx™ next generation growth factor technology supplement the growth factors already present in your skin. The Regenica® system was shown to be safe in four separate clinical studies. In addition, MRCx™ underwent a full battery of pre-clinical testing and showed no signs of toxicity. Additional testing demonstrated no irritation in skin and ocular studies, and no allergenicity. MRCx™ was also tested against cancer cells and the results were published in the oncologic literature. Suneva’s Medical Affairs department would be happy to discuss the oncology results further with you.

Which specific growth factors are in Regenica®?

The MRCx™ in Regenica® has been tested for over 100 growth factors and proteins. The exact mix of growth factors is proprietary, but the clinical results speak for themselves.

How do growth factors penetrate the skin?

Growth factors are large molecules, but they can penetrate the stratum corneum of the epidermis through follicles where the skin is thinner, through pores, and directly through the intra-follicular epidermis. As signaling proteins, they may trigger an underlying cascade in addition to having an effect through direct penetration.

Does Regenica® contain stem cells?

Regenica® does not use stem cells. The Regenica® proprietary, patented process begins by harvesting fibroblasts from a neonatal cell bank and conditioning them in pure, bovine-free media. During the conditioning process, the cells are suspended, gently stirred, and exposed to low oxygen levels. This process creates an embryonic-like environment which allows the cells to revert back to an earlier state and exhibit stem cell properties. They release multipotent growth factors which are then collected to make MRCx™.

Why should I carry Regenica®?

Growth factors are a key part of a balanced skin care regimen. They supplement the growth factors in your skin that decline with age. But not all growth factors are alike. The growth factors in Regenica® are unique. They’ve been specifically created to be multipotent, Backed by sound science, solid clinical efficacy, and safety data, the Regenica® system can give your practice a clear edge. In addition, Regenica® provides comprehensive aesthetician support to assist you in meeting your patient’s needs. Contact your Suneva sales representative for more information.

How long has Regenica® been on the market?

After years of advanced research and development, Regenica® was launched by the original scientific founder in 2009. In 2012, Regenica® became exclusively available through Suneva Medical

Who makes and sells Regenica®?

Regenica® was developed by Dr. Gail Naughton at Histogen, Inc. and licensed to Suneva Medical for distribution in 2012.

Where is Regenica® available for purchase?

Regenica® is available only through physicians’ practices. Contact Suneva Medical to learn how to carry Regenica® in your pracitce.

How can I order Regenica®?

Contact a Suneva sales consultant by calling 1-888-278-3345 or send us a message for more information.

Regenica® Rejuvenating Dual Serum is a revolutionary breakthrough in skincare. The twin chambers delivers both a 95% concentration of patented MRCx™ next generation growth factor technology and a powerful formula of over ten skin-essential ingredients including advanced copper peptides, amino acids, anti-oxidants, and plant-based extracts. Regenica® Rejuvenating Dual Serum puts modern technology to work to reveal your most beautiful asset – your skin.

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What is Regenica® Renew SPF 15?

Regenica® Renew SPF 15 helps protect skin from harmful UV rays. It’s the only UV protectant formulated with MRCx™ next generation growth factor technology to enhance skin’s natural repair and renewal and help prevent the signs of aging.

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Do Renew SPF 15 and Replenishing Crème need to be used together?

Regenica® Renew SPF 15 and Replenishing Crème can be used individually, but the clinical studies evaluated results when used together. Both products contain MRCx™ to deliver a twice daily dose of growth factors for more potent results.

What is the shelf life of Renew SPF 15?

Please refer to the expiration date on outer packaging.

What is Regenica® Replenishing Crème?

Regenica® Replenishing Crème hydrates skin and helps reverse the signs of aging. The combination of MRCx™ next generation growth factor technology, powerful peptides, and advanced moisturizers replenishes what you lose over time. Nourish your skin and reveal your most radiant complexion.

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Can Replenishing Crème and Renew SPF 15 be used together?

Regenica®Replenishing Crème and Renew SPF 15 can be used individually, but the clinical studies evaluated results when used together. Both products contain MRCx™ to deliver a twice daily dose of growth factors for more potent results.

Regenica® Repair Complex helps enhance skin renewal. Made with MRCx™ next generation growth factor technology, it’s specifically formulated for sensitive skin. Help restore your skin to its optimal health.

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Regenica® Revitalizing Eye Crème is specifically formulated for the delicate area around the eye. It’s a revolutionary formulation of MRCx™ next generation growth factor technology with advanced peptides, powerful antioxidants, and superior moisturizing agents. Regenica® Revitalizing Eye Crème quickly softens the look of fine lines and wrinkles while reducing the appearance of puffiness and dark under eye circles.

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Regenica® Recovery Gel is a soothing balm that helps quickly heal skin. It infuses MRCx™ next generation growth factor technology with the most trusted natural anti-inflammatory and calming agents, including arnica, vitamin K, aloe vera, beta-glucan, and SymCalmin®. Help reverse the signs that your skin was ever less than perfect.

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What is the clinical data behind Regenica®?

Four clinical studies have been conducted on Regenica®. Two of the trials studied the effects of Regenica® after a laser treatment and were published in peer-reviewed journals. They found that Regenica® enhanced healing after a laser procedure. Two anti-aging studies showed that using Regenica® resulted in smoother skin texture and tone as well as a reduction in the appearance of fine lines and wrinkles. In addition, a consumer preference survey demonstrated that consumers preferred the effects and aesthetics of Regenica® over TNS® Essential Serum.

What were the results of the post-laser studies?

Two trials were published evaluating the effects of MRCx™ in the post-laser setting.The first proof of concept study was a double-blind, full-face comparison of Regenica® vs. placebo in which all subjects were allowed to use petrolatum as needed. There was a statistically significant reduction in the need for petrolatum use in the Regenica® group and a trend towards reduced erythema by day 3 post laser. The second study was a double-blind, split-face design comparing MRCx™ vs. control. There were statistically significant reductions in transepidermal water loss (TEWL) in the Regenica® group by day 3 and visible improvements in edema and erythema in the treated subjects.

What were the results of the anti-aging studies?

Two (unpublished) anti-aging studies were conducted. The first study was a single-blind study evaluating 14 subjects who used Regenica® Renew SPF 15 (formerly Day Repair SPF 15) and Replenishing Crème (formerly Overnight Repair). 90% saw a reduction in pore size, 82% noted improved skin texture, and 64% noted more radiant skin. A second single-blind study evaluated 18 subjects who used Regenica® Renew SPF 15 (formerly Day Repair) and Replenishing Crème (formerly Overnight Repair). The investigator noted statistically significant improvements in the appearance of skin tone, texture, wrinkles, radiance, translucency, and blotchiness. 100% of subjects were satisfied and would recommend Regenica® to a friend.

What were the results of the consumer preference survey?

We put Regenica® to the Growth Factor Challenge. In a blind, split-face survey, consumers compared Regenica® (Replenishing Crème) to TNS® Essential Serum. Over 2/3rds of users preferred Regenica® overall and ~80% preferred the smell of Regenica® to TNS®. Over 60% felt that Regenica® left their skin feeling moisturized and improved their skin texture.

What were the results of the Revitalizing Eye Crème Open-Label, Proof of Concept Study?

38 women were asked to use Regenica Revitalizing Eye Crème in their under eye and crow’s feet areas for 60 days. Marked clinical improvement was observed by both investigators and subjects alike. 80% of subjects responded that they would recommend Regenica Revitalizing Eye Crème to a friend. 48% of subjects noted improvement in the appearance of under eye fatigue, 46% noted improvement in the appearance of the severity of crow’s feet lines and wrinkles. Subjects felt they had improved hydration in both the under eye (63.8% improvement) and crow’s feet area (50.4% improvement). Investigators rated 63% of subjects as much improved/improved by day 60. Almost all subjects found the product to be: Non-greasy, Easy to apply and Fast-absorbing.

Are there any side effects?

Clinical studies showed that no treatment-related adverse events (e.g. irritant or allergic dermatitis) were reported. As with any skin care product, some patients may experience irritation, redness, and sensitivity.

When can one expect to see results?

Immediately after use, patients may see significant improvement in skin hydration. In clinical studies, subjects using Regenica® Renew SPF 15 and Replenishing Crème saw significant results in as little as two weeks. Subjects using Rejuvenation Complex had improved healing in as little as three to five days. The best results are seen with continued use.

How does skin repair and regenerate?

Skin cells are constantly proliferating, differentiating, and exfoliating. Maintaining this activity, and upregulating and downregulating activities in response to stressors, is intricately managed in part by growth factors. At any one time, there may be hundreds of growth factors acting together to preserve the balance and ensure optimum skin health. Growth factors signal natural repair and renewal.

What are the effects of aging on skin?

As we age, the accumulated damage of past environmental exposure and intrinsic reduction in collagen and elastin formation outpace the skin’s ability to effectively remodel. The equilibrium is tipped. Young basal cells proliferate at a slower rate, are less effective at differentiating, and are less effective at pushing up towards the epidermis. More mature superficial cells are less efficient at turning over and exfoliating. Dermal cells produce less collagen and elastin and what is formed may be laid down in an irregular, disorganized pattern changing the skin’s properties. The clinical results are dull, crepey, sagging skin, uneven texture and tone, and fine lines and wrinkles.

What is the effect of environmental damage?

The majority of environmental damage is caused by UV rays, but pollution, smoke, and harsh weather can also contribute to skin aging. Shorter UVB rays are responsible for skin reddening and burning. They affect the most superficial layers of epidermis causing cells to thicken and darken. Longer UVA rays have a more direct effect on the deeper layers of the epidermis where melanocytes and more connective tissue reside. Exposure to both can cause direct DNA damage and the release of free radicals. The toxic effects lead to a breakdown of collagen and elastin and an irregular pattern of new collagen and elastin formation. And of course, DNA damage can lead to skin cancer.